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Title   방사선 치료에 따른 암환자의 말초혈액 T 및 B 림프구의 분포 및 기능변화 ( Changes in the Distribution and Function of Lymphocytes in Peripheral Blood of Cancer Patients Undergoing Radiotherapy )
Publicationinfo   1992 Jan; 024(01): 64-73.
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Abstract   The role of immunological factors in the development and course of human malignancy has been extensively studied, and evidence now indicates that an impaired immunity may affect the clinical response and prognosis of cancer patients. If the hosts immune status is important in its defense against cancer, it is imperative that the varying effects of treatment modalities on the immune system be evaluated. This study was designed to detennine the extent and duration of changes in the serum IRG level, proportion and proliferative responses of T and B cells, and differentiation responses of B cells of peripheral blood obtained from each cancer patient undergoing therapeutic irradiation. Radiation affected neither significant changes in the mean values nor IgG-secreting response of B lymphocytes. During irradiatian, the mean numbers of lymphocytes were decreased, varying from 44.3 percent to 48.2 vercent of pretreatment baseline. But this decrement was restored after completion of treatment. A decrease in proliferative response of mitogenstimulated lymphocytes was also noted during radiation. This radiation-induced depression of T cell proliferation was almost recovered to the pretreament values by 6-week post-irradiation, but that of B lymphocytes persisted unt.il about 12 weeks after completion of therapy.
저 자   권형철(Hyung Chul Kwon),김정수(Jung Soo Kim),이정호(Jeong Ho Lee)